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Year : 2016  |  Volume : 17  |  Issue : 3  |  Page : 162-166

Effect of diabetic retinopathy on retinal nerve fiber layer thickness

Department of Ophthalmology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Correspondence Address:
Mohammad A.M. El-Hifnawy
Department of Ophthalmology, Faculty of Medicine, University of Alexandria, Alexandria 21521
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-9173.195262

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Purpose The objective of this study was to assess the effect of diabetic retinopathy (DR) on the retinal nerve fiber layer (RNFL) thickness. Patients and methods This study included 30 diabetic patients having nonproliferative diabetic retinopathy (NPDR) without macular edema, 20 diabetic patients without DR, and 20 healthy nondiabetic age-matched individuals as a control group. In each patient one eye was included. Patients were evaluated for RNFL thickness by Heidelberg Spectralis optical coherence tomography. Results The global (G), the superior, and the temporal RNFL thickness in the diabetic patients without DR was significantly less than that of the control group and that of the patients with NPDR. However, there was no statistically significant difference between the patients with NPDR and the control group. It was noted that there was no statistically significant difference in the RNFL thickness of the inferior and nasal quadrants between the three studied groups. Conclusion Early retinal neurodegeneration can occur before retinal microvascular diabetic changes can be observed.

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